NEG+ | Dr. Jimmy Belotte

PUBLICATIONS

ABSTRACTS

PRESENTATIONS

LECTURES

NEW ENGLAND GYNECOLOGY PLLC

Publications &
Presentations

A record of peer-reviewed scholarship, international presentations, and invited lectures spanning gynecologic oncology, translational science, cancer prevention, and reproductive medicine — spanning more than 15 years of active investigation.

13

PEER-REVIEWED PUBLICATIONS

20

PUBLISHED ARTIFACTS

31+

PRESENTATIONS & LECTURES

3

AD-HOC REVIEWER JOURNALS

PEER-REVIEWED

PUBLISHED ABSTRACTS

NON-PEER REVIEWED

PRESENTATIONS

INVITED LECTURES

REPORTS OF ORIGINAL WORK · CASE REPORTS · REVIEW ARTICLES

Peer-Reviewed
Publications

Citation source: Google Scholar. Impact factor source: respective journal websites.

LANDMARK CONTRIBUTIONS

ORIGINAL RESEARCH

2024 · LANDMARK

Comparing niraparib versus platinum-taxane doublet chemotherapy as neoadjuvant treatment in patients with newly diagnosed homologous recombination-deficient stage III/IV ovarian cancer: study protocol for cohort C of the open-label, phase 2, randomized controlled multicenter OPAL trial.

Belotte J, Felicetti B, Baines AJ, YoussefAgha A, Rojas-Espaillat L, Ortiz AG, Provencher D, Vázquez RM, Cortijo LG, Zeng X.

Trials. 2024 May 4;25(1):301.

2022 · LANDMARK

OVARIO phase II trial of combination niraparib plus bevacizumab maintenance therapy in advanced ovarian cancer following first-line platinum-based chemotherapy with bevacizumab (NCT03326193).

Hardesty MM, Krivak TC, Wright GS, Hamilton E, Fleming EL, Belotte J, Keeton EK, Wang P, Gupta D, Clements A, Gray HJ, Konecny GE, Moore RG, Richardson DL.

Gynecologic Oncology. 2022 Jun 8; S0090-8258(22)00331-6.

ORIGINAL RESEARCH · 2017

Specific point mutations in key redox enzymes are associated with chemoresistance in epithelial ovarian cancer.

Fletcher NM, Belotte J, Saed MG, Memaj I, Diamond MP, Morris RT, Saed GM.

Free Radical Biology and Medicine. 2017 Jan;102:122–132.

ORIGINAL RESEARCH · 2016

The Role of Angiogenesis in the Persistence of Chemoresistance in Epithelial Ovarian Cancer.

Nusrat O, Belotte J, Fletcher NM, Memaj I, Saed MG, Diamond MP, Saed GM.

Reproductive Sciences. 2016 Apr 26. pii: 1933719116645191.

ORIGINAL RESEARCH · 2015

A Single Nucleotide Polymorphism in Catalase Is Strongly Associated with Ovarian Cancer Survival.

Belotte J, Fletcher NM, Saed MG, Abusamaan MS, Dyson G, Diamond MP, Saed GM.

PLOS ONE. 2015 Aug 24;10(8):e0135739.

ORIGINAL RESEARCH · 2015

Sox2 gene amplification significantly impacts overall survival in serous epithelial ovarian cancer.

Belotte J, Fletcher NM, Alexis M, Morris RT, Munkarah AR, Diamond MP, Saed GM.

Reproductive Sciences. 2015 Jan;22(1):38–46.

2014 · LANDMARK

The role of oxidative stress in the development of cisplatin resistance in epithelial ovarian cancer.

Belotte J, Fletcher NM, Awonuga AO, Alexis M, Abu-Soud HM, Saed MG, Diamond MP, Saed GM.

Reproductive Sciences. 2014 Apr;21(4):503–8.

ORIGINAL RESEARCH · 2012

Myeloperoxidase and free iron levels: potential biomarkers for early detection and prognosis of ovarian cancer.

Fletcher NM, Jiang Z, Ali-Fehmi R, Levin NK, Belotte J, Tainsky MA, Diamond MP, Abu-Soud HM, Saed GM.

Cancer Biomarkers. 2012;10(6):267–75.

CASE REPORTS

CASE REPORT · 2014

Successful laparoscopic management of ruptured tubal pregnancy with an ipsilateral ectopic pelvic kidney.

Belotte J, Belotte J, Alexis M, Awonuga AO, Aguin TJ.

Case Reports in Obstetrics and Gynecology. 2014;2014:682737.

CASE REPORT · 2012

Platinum-based combination chemotherapy for the treatment of advanced-stage squamous cell carcinoma of the vulva.

Belotte J, Awonuga AO, Bolinjkar R, Alexis M, Tabassum F, Deppe G.

Obstetrics & Gynecology. 2012 Aug;120(2 Pt 2):458–60.

CASE REPORT · 2011

Small bowel obstruction subsequent to Essure microinsert sterilization: a case report.

Belotte J, Shavell VI, Awonuga AO, Diamond MP, Berman JM, Yancy AF.

Fertility and Sterility. 2011 Jul;96(1):e4–6.

REVIEW ARTICLES

REVIEW · 2014

Advances in the Pathogenesis of Adhesion Development: The Role of Oxidative Stress.

Awonuga AO, Belotte J, Abuanzeh S, Fletcher NM, Diamond MP, Saed GM.

Reproductive Sciences. 2014 Feb;21(7):823–836.

REVIEW · 2013

Chemotherapy of vulvar cancer: a review.

Deppe G, Mert I, Belotte J, Winer IS.

Wiener Klinische Wochenschrift. 2013 Mar;125(5–6):119–28.

CONFERENCE PROCEEDINGS & PUBLISHED ABSTRACTS

Published
Abstracts

20 published abstracts spanning GSK Phase 1/2 oncology trials, OVARIO, and foundational ovarian cancer science presented at SGO, AACR, SRI, ASRM, and AAGL.

JCO · 2025

A phase 1/2 dose escalation study of the oral DNA polymerase theta inhibitor (POLQi) GSK4524101 ± niraparib in adults with advanced or metastatic solid tumors.

Samnotra V, Belotte J, Shtessel L, Hanafin P, Pannirselvam M, Bhaskar A, Krishnatry AS, Rogan D, Yuzugullu H, Barve MA, Bedard P, Chu QS, Munster PN, Spira AI, Saleh RR, Sommerhalder D, Yap TA, Van Tine BA, Sanicola-Nadel M.

Journal of Clinical Oncology. Volume 43, Number 16_suppl. TPS3174. 2025.

SGO · 2025

A phase 2 study of niraparib plus bevacizumab maintenance following front-line platinum-based chemotherapy with bevacizumab in advanced ovarian cancer: final analysis from the OVARIO study.

Hardesty MM, Krivak TC, Wright GS, et al. including Belotte J.

SGO Annual Meeting on Women’s Cancer. Abstract 836266. Seattle, WA. March 14–17, 2025.

GYNECOL ONCOL · 2023

Open-label, phase 2, randomized controlled multicenter study comparing niraparib versus platinum-taxane doublet chemotherapy as neoadjuvant treatment in participants with homologous recombination deficient stage III/IV ovarian cancer: Trial in progress.

Zeng X, Belotte J, Felicetti B, Baines A, YoussefAgha A, Rojas-Espaillat L, Ortiz AG, Provencher D, Vázquez RM, González-Cortijo L.

Gynecologic Oncology. Abstract 1252. 2023.

GYNECOL ONCOL · 2022

Phase 2 OVARIO Study of Niraparib + Bevacizumab Therapy in Advanced Ovarian Cancer Following Frontline Platinum-Based Chemotherapy with Bevacizumab.

Hardesty MM, Krivak TC, Wright GS, Hamilton E, Fleming EL, Belotte J, Keeton EK, Wang P, Clements A, Gray HJ, Konecny GE, Moore RG, Richardson DL.

Gynecologic Oncology. Open Access. June 8, 2022.

GYNECOL ONCOL · 2021

Phase II OVARIO Study of niraparib + bevacizumab therapy in advanced ovarian cancer following front-line platinum-based chemotherapy with bevacizumab.

Hardesty MM, Krivak TC, Wright GS, Hamilton E, Fleming EL, Belotte J, Keeton E, Chen J, Clements A, Gray H, Konecny G, Moore R, Richardson D.

Gynecologic Oncology. Volume 162, Supplement 1. 2021. Page S17.

REPROD SCI · 2016

Glutathione Peroxidase Significantly Increased Proliferation of Both A2780 and A2780Cis Ovarian Cancer Cell Lines.

Belotte J, Fletcher NM, Saed MG, Diamond MP, Saed GM.

Reproductive Sciences. Vol. 23, Supplement 1, Late-Breaking Abstract. March 2016.

REPROD SCI · 2016

Chemoresistant Ovarian Cancer Cells Manifest Lower Vascular Endothelial Growth Factor and Hypoxia Inducible Factor-1α: A Potential Survival Mechanism.

Nusrat O, Belotte J, Fletcher NM, Dai J, Memaj I, Saed GM.

Reproductive Sciences. Vol. 23, Supplement 1, Page 178A, Abstract T-250. March 2016.

REPROD SCI · 2016

Chemotherapy Induces a Genotype Switch in Key Antioxidant Enzymes: A Potential Mechanism of Chemoresistance in Epithelial Ovarian Cancer Cells.

Fletcher NM, Belotte J, Saed MG, Abusamaan MS, Diamond MP, Saed GM.

Reproductive Sciences. Vol. 23, Supplement 1, Page 262A, Abstract F-248. March 2016.

REPROD SCI · 2016

Exposure to Recombinant Anti-Mullerian Hormone (AMH) Downregulates Ovarian Follicle Cells’ Stemness Potential in Fresh and Vitrified/Thawed Ovarian Cortex.

Detti L, Fletcher NM, Uhlmann RA, Belotte J, Williams LJ, Saed GM.

Reproductive Sciences. Vol. 23, Supplement 1, Page 180A, Abstract T-257. March 2016.

CLIN CANCER RES · 2015

Superoxide dismutase significantly reversed the development of cisplatin resistance in epithelial ovarian cancer.

Belotte J, Nusrat O, Fletcher NM, Saed MG, Neubauer BR, Abu-Soud HM.

Clinical Cancer Research. Volume 21, Issue 4 Supplement. Abstract B01. Published February 13, 2015.

FERTIL STERIL · 2014

The in-vivo effects of superoxide dismutase on the incidence and severity of post-operative adhesion development.

Awonuga AO, Fletcher NM, Nusrat O, Saed MG, Abusamaan MS, Belotte J, Diamond MP, Saed GM.

Fertility and Sterility. Volume 102, Issue 3 Supplement, Page e73. Abstract O-213. August 2014.

REPROD SCI · 2014

SNPs in Key Oxidants and Antioxidants are Associated with Increased Risk and Serve as Potential Targets for Ovarian Cancer.

Saed MG, Saed GM, Fletcher NM, Belotte J, Levin NK, Tainsky MA, Diamond MP.

Reproductive Sciences. Vol. 21, No. 3 (Supplement 1), Page 213A, Abstract T-249. March 2014.

REPROD SCI · 2014

Dichloroacetate Increases Sensitivity to Chemotherapy by Modulation of Antioxidants in Epithelial Ovarian Cancer.

Fletcher NM, Belotte J, Saed GM, Abu-Soud HM, Diamond MP, Saed GM.

Reproductive Sciences. Vol. 21, No. 3 (Supplement 1), Page 207A, Abstract T-228. March 2014.

REPROD SCI · 2014

Sox2 Gene Amplification Impacts Survival in Epithelial Ovarian Cancer.

Belotte J, Fletcher NM, Diamond MP, Saed GM.

Reproductive Sciences. Vol. 21, No. 3 (Supplement 1), Page 204A, Abstract T-219. March 2014.

CLIN CANCER RES · 2014

The role of oxidative stress in the development of cisplatin resistance in epithelial ovarian cancer.

Belotte J, Fletcher NM, Levin NK, Simon MS, Abu-Soud HM, Diamond MP, Tainsky MA, Saed GM.

Cancer Research. Volume 73, Issue 8 Supplement. Abstract LB-356. Published November 18, 2014.

CLIN CANCER RES · 2013

Catalase and NADPH oxidase single nucleotide polymorphisms are associated with increased risk and serve as potential targets for breast and ovarian cancers.

Belotte J, Fletcher NM, Levin NK, Simon MS, Abu-Soud HM, Diamond MP, Tainsky MA, Saed GM.

Cancer Research. Volume 73, Issue 8 Supplement. Abstract LB-356. Published November 18, 2014.

REPROD SCI · 2012

Dichloroacetate increases sensitivity to chemotherapy treatment of epithelial ovarian cancer cells.

Fletcher NM, Belotte J, Diamond MP, Saed GM.

Reproductive Sciences. Vol. 19, 3 Supplement, pp. 1A–70A. March 2012.

JMIG · 2012

Persistent Trophoblastic Implant on the Right Ovary after Laparoscopic Salpingectomy for Ectopic Pregnancy. A Case Report.

Bolinjkar RS, Belotte J, Hussein Y, Dean M, Hendrix S.

Journal of Minimally Invasive Gynecology. Vol. 19, Issue 6, Supplement, Pages S162–S163. October 2012.

JMIG · 2011

Case Report for Uretero-Vaginal Fistula: A Delayed Complication of Robotic Surgery.

Bolinjkar RS, Belotte J.

Journal of Minimally Invasive Gynecology. Vol. 18, Issue 6, Supplement, Page S158. October 2011.

JMIG · 2010

Small Bowel Obstruction Due to Essure Micro-Insert Migration.

Belotte J, Filetti CL, Shavell VI, Berman JM, Yancy AF.

Journal of Minimally Invasive Gynecology. Vol. 17, Issue 6, Supplement, Page S74. October 2010.

NON-PEER-REVIEWED PUBLICATIONS

Public &
Professional Writing

OP-ED · 2016

Increasing HPV Immunization Rate as an Elegant Strategy to Reduce Cancer Health Disparities in Michigan: Killing Two Birds With One Stone!

Belotte J.

PROFESSIONAL · 2016

WCMSSM and MSMS Physician Leaders Head to Washington, DC.

Belotte J.

PODIUM & POSTER PRESENTATIONS

Scientific
Presentations

Refereed and non-refereed podium and poster presentations at international, national, and regional scientific meetings.

PODIUM PRESENTATIONS — REFEREED

PODIUM · REFEREED

“The Role of Oxidative Stress in the Establishment of Cisplatin Resistance in Epithelial Ovarian Cancer Cells: Additional Evidence”

NIH Women’s Reproductive Health Research (WRHR) Retreat

Augusta, GA · December 1–2, 2016

PODIUM · REFEREED

“Small Bowel Obstruction Due to Essure Micro-Insert Migration”

AAGL Global Congress of Minimally Invasive Gynecology — 39th Annual Meeting

Las Vegas, NV · November 2010

POSTER PRESENTATIONS — REFEREED

PODIUM · NON-REFEREED​

“The in-vivo effects of superoxide dismutase on the incidence and severity of post-operative adhesion development after cecal abrasion”

3rd Annual C.S. Mott Center Scientific Retreat — Wayne State University

Detroit, MI · May 15, 2013

PODIUM · NON-REFEREED

“A novel association between a catalase single nucleotide polymorphism and increased risk of ovarian cancer”

3rd Annual C.S. Mott Center Scientific Retreat — Wayne State University

Detroit, MI · May 15, 2013

POSTER PRESENTATIONS — REFEREED

POSTER · REFEREED

“Clinical Survival Outcomes Trend of Squamous Vaginal Cancer In The United States: A SEER Based Study”

NIH WRHR Retreat

Augusta, GA · December 1–2, 2016

POSTER · REFEREED​

“Glutathione Peroxidase Significantly Increased Proliferation of Both A2780 and A2780Cis Ovarian Cancer Cell Lines”

Society for Reproductive Investigation — 63rd Annual Scientific Meeting

Montreal, Canada · March 16–19, 2016

POSTER · REFEREED​

“Chemoresistant Ovarian Cancer Cells Manifest Lower VEGF and HIF-1α: A Potential Survival Mechanism”

Society for Reproductive Investigation — 63rd Annual Scientific Meeting

Montreal, Canada · March 16–19, 2016

POSTER · REFEREED​

“Chemotherapy Induces a Genotype Switch in Key Antioxidant Enzymes: A Potential Mechanism of Chemoresistance”

Society for Reproductive Investigation — 63rd Annual Scientific Meeting

Montreal, Canada · March 16–19, 2016

POSTER · REFEREED​

“The in-vivo effects of superoxide dismutase on post-operative adhesion development”

ASRM 70th Annual Meeting

Honolulu, HI · October 18–22, 2014

POSTER · REFEREED​

“Superoxide dismutase significantly reversed the development of cisplatin resistance in epithelial ovarian cancer”

AACR Precision Medicine Series: Drug Sensitivity and Resistance

Orlando, FL · June 18–21, 2014

POSTER · REFEREED​

“SNPs in Key Oxidants and Antioxidants are Associated with Increased Risk and Serve as Potential Targets for Ovarian Cancer”

SGI 61st Annual Scientific Meeting — Florence, Italy

Florence, Italy · March 26–29, 2014

POSTER · REFEREED​

“Dichloroacetate Increases Sensitivity to Chemotherapy by Modulation of Antioxidants in Epithelial Ovarian Cancer”

SGI 61st Annual Scientific Meeting — Florence, Italy

Florence, Italy · March 26–29, 2014

POSTER · REFEREED​

“Sox2 Gene Amplification Impacts Survival in Epithelial Ovarian Cancer”

SGI 61st Annual Scientific Meeting — Florence, Italy

Florence, Italy · March 26–29, 2014

POSTER · REFEREED

“The role of oxidative stress in the development of cisplatin resistance in epithelial ovarian cancer”

AACR Special Conference

Miami, FL · September 18–21, 2013

POSTER · REFEREED

“Catalase and NADPH oxidase SNPs are associated with increased risk and serve as potential targets for breast and ovarian cancers”

AACR 2013 Annual Meeting — Washington Convention Center

Washington, DC · April 10, 2013

POSTER · REFEREED

“Dichloroacetate increases sensitivity to chemotherapy treatment of epithelial ovarian cancer cells”

SGI 59th Annual Scientific Meeting

San Diego, CA · March 21–24, 2012

POSTER · REFEREED

“Persistent Trophoblastic Implant on the Right Ovary after Laparoscopic Salpingectomy for Ectopic Pregnancy”

AAGL Global Congress — 41st Annual Meeting

Las Vegas, NV · November 2012

POSTER · REFEREED

“Case Report for Uretero-Vaginal Fistula: A Delayed Complication of Robotic Surgery”

AAGL Global Congress — 40th Annual Meeting

Hollywood, FL · November 2011

POSTER · REFEREED

“Platinum based combination chemotherapy for the treatment of advanced stage squamous cell carcinoma of the vulva”

Michigan Section, ACOG — Junior Fellow Research Day

Lansing, MI · May 2011

POSTER · REFEREED

“Small Bowel Obstruction Subsequent to Essure Micro-Insert Sterilization: A Case Report”

Michigan Section, ACOG — Junior Fellow Research Day

Lansing, MI · May 2011

INTERNATIONAL, NATIONAL & REGIONAL

Invited
Lectures & Presentations

INTERNATIONAL / NATIONAL

2018

“Cancer Preventative Care: A Focus on HPV Vaccination and Gynecologic Cancers”

AMHE 45th Annual Convention — Medicine of Today and Tomorrow. Decameron, Baru-Cartagena, Colombia. July 24, 2018.

2010

“Management of Bowel Obstruction in the Setting of Ovarian Cancer”

MD Anderson Cancer Center. Houston, TX. May 2010.

2009

“Hormonal Disorders”

Nassau University Medical Center. East Meadow, NY. November 2009.

2009

“Diagnostic and Operative Laparoscopy”

Nassau University Medical Center. East Meadow, NY. April 2009.

LOCAL / REGIONAL

2018

Cervical Cancer Screening — Resident Lecture Series

OB/GYN Residency Program, Montefiore Albert Einstein College of Medicine. Bronx, NY. August 14, 2018.

2017

Updates on Ectopic Pregnancy — Fellow Lecture Series

Pediatrics Emergency Medicine, Children’s Hospital of Michigan, Detroit Medical Center. Detroit, MI. October 11, 2017.

2017

“The Role of Oxidative Stress in the Establishment of Cisplatin Resistance in Epithelial Ovarian Cancer Cells: Additional Evidence”

Albert Einstein College of Medicine, Dept. of OB/GYN and Women’s Health. Bronx, NY. September 25, 2017.

2017

“Cancer Preventative Care: A Focus on HPV Vaccination”

Vaccine for Children (VFC) Provider Meeting Program. Cadillac Place, Detroit, MI. July 19, 2017.

2017

“Vaccines for Women’s Health: An Update for the Obstetrician/Gynecologist”

Michigan Physician Peer Education Project on Immunizations. Grand Rounds — Wayne State OB/GYN, Detroit Medical Center, Harper/Hutzel Hospital. May 2, 2017.

2017

Cancer Preventative Care: A Rare Opportunity to Reduce Both the Cancer Burden and Cancer Health Disparities — A Focus on HPV Vaccination and Gynecologic Cancers”

Grand Rounds — OB/GYN, St. John Hospital & Medical Center. Detroit, MI. March 13, 2017.

2017

“Advances and New Opportunities for Cancer Preventative Care for the OBGYN Generalist. HPV Vaccination as Means to Reduce the Cancer Burden and Cancer Health Disparities in the Urban Setting”

Grand Rounds — OB/GYN, St. John Hospital & Medical Center. Detroit, MI. March 13, 2017.

2016

“A Single Nucleotide Polymorphism in Catalase Is Strongly Associated with Ovarian Cancer Survival”

C.S. Mott Center for Human Growth and Development. March 31, 2016.

2015

“Haïti: Past, Present and Future” — Keynote Speaker

Haitian Network Group of Detroit. Farmington Main Library, Farmington Hills, MI. February 15, 2015.

2014

“New Insights into Cancer Issues in Women”

NAAMA MI Symposium — Women’s Health for the Primary Care Provider. Embassy Suites Southfield, MI. November 1, 2014.

2013

“Epithelial Ovarian Cancer, Chemotherapy and Cisplatin Resistance”

Dept. of OB/GYN, Division of Gynecologic Oncology — Wayne State University / Karmanos Cancer Institute. Detroit, MI. January 2013.

2013

“Epithelial Ovarian Cancer, Chemotherapy and Cisplatin Resistance” — Brown Bag Seminar Series

C.S. Mott Center for Human Growth and Development, Wayne State University. Detroit, MI. April 2013.

2012

“Diagnostic and Operative Laparoscopy”

Dept. of OB/GYN, Division of Gynecology — Wayne State University / Karmanos Cancer Institute. Detroit, MI. July 2012.

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